| Current status in research of dengue vaccine candidates based on domain Ⅲof E protein |
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| 引用本文： | 孟胜利,孙燕.Current status in research of dengue vaccine candidates based on domain Ⅲof E protein[J].国际生物制品学杂志,2010,34(6):72-76. |
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| 作者姓名： | 孟胜利 孙燕 |
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| 作者单位： | 武汉生物制品研究所狂犬病疫苗室,430060;中南民族大学武汉神经科学和神经工程研究所,430074; |
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| 摘 要： | The ideal dengue vaccines should be low reactogenic, induce life-long protection against infection with any of the four serotypes of dengue viruses, and be affordable. The envelope protein domain Ⅲ of dengue virus has been implicated in receptor binding, and it is also the target of specific neutralizing antibodies.In this article, the current state of knowledge on vaccine candidates based on domain Ⅲ is reviewed.
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| 关 键 词： | 登革热病毒 病毒包膜蛋白质类 结构域Ⅲ 登革热疫苗 Domain Ⅲ |
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