Human β-defensin-2 and skin diseases |
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作者姓名: | 常小丽 季必华 |
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作者单位: | 皖南医学院弋矶山医院皮肤性病科,安徽省芜湖市,241001; |
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基金项目: | 皖南医学院中青年科研基金 |
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摘 要: | Human β-defensin-2 (hBD-2) is an endogenous antimicrobial peptide recently found in the skin with broad-spectrum antimicrobial activity and unique mechanism of function. Recent studies have confirmed that the expression of hBD-2 is upregulated in the lesions of some dermatoses, such as psoriasis,acne vulgaris, verruca, dermatophytosis and basal cell carcinoma, etc. The susceptibility to bacterial and viral infections may be associated with the decreased or absent expression of hBD-2. Further researches into HBD-2will provide a new direction for the prevention and treatment of skin diseases.
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关 键 词: | 皮肤疾病 β防御素 研究 β-defensins |
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