生物相容性材料作用机制研究进展

生物材料与组织的相互作用是生物材料学科多年关注的焦点,是生物相容性学科的基础.生物材料研究通过对生物相容现象的探讨为生物型医疗器械的使用提供了更好的依据.分析过去50年无源医疗器械的使用情况,在大多数情况下,材料不损伤组织是长期使用医疗器械生物相容性的惟一要求.目前只有少数具有活性的生物材料可成功应用于临床.就生物材料在组织工程、复杂细胞、药物和基因传递系统以及生物技术方面的应用进行综述,并说明生物材料和组织之间的相互作用.

Research progress in mechanisms of biocompatibility

The interaction of biomaterials and tissues has been the focus of biomaterial science for many years and formed the foundation of the subject of biocompatibility. The research about biomaterials provides better basis for biomedical devices by the understanding of biocompatibility phenomena. In this paper, over 50 years of experience with such devices is analysed and it is shown that, in the vast majority of circumstances, the sole requirement for biocompatibility in a medical device intended for long-term contact with the tissues of the human body is that no harm should be brought to those tissues. Only a few bio-active biomaterials has been applied successfully in clinics. This artical gives a review on the application of biomaterials in tissue engineering,sophisticated cells, drug and gene delivery systems and in biotechnology. Interactions between biomaterials and tissue components is discussed as well.