内皮抑素及其在肿瘤治疗中的应用研究进展

Endostatin as an endogenous angiogenesis inhibitor can inhibit the tumor angiogenesis through the inhibition of vascular endothelial cell migration by variety of mechanisms, thereby inhibiting the growth of tumor. The effect of combination of endostatin, radiotherapy and chemotherapy is remarkable. In addition, endostatin as a tumor marker with special drug delivery systems has brought a breakthrough in treatment of tumor. Injection of recombinant human endostatin can enhance the anti-tumor effect greatly, and it has entered Phase Ⅲ experimental study. Small molecular endostatin can be purified easily by using the technology of site-directed mutagenesis. Not only can it low the cost of mass production, but also it can provide a broad prospect in the treatment of cancer. In this paper, we provide a review of the progress in the structure of endostatin,anti-tumnor mechanism and the application in cancer therapy.

Current progression of endostar on clinical application and research