| 增食欲素调节下丘脑-垂体-肾上腺轴的研究进展 |
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| 引用本文： | 王露,赵玉岩. 增食欲素调节下丘脑-垂体-肾上腺轴的研究进展[J]. 国际内分泌代谢杂志, 2010, 30(1): 22-25. DOI: 10.3760/cma.j.issn.1673-4157.2010.s1.008 |
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| 作者姓名： | 王露 赵玉岩 |
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| 作者单位： | 中国医科大学附属第一医院内分泌科,沈阳,110001; |
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| 基金项目： | 国家自然科学基金辽宁省教育厅自然科学基金资助项目 |
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| 摘 要： | 增食欲素A和增食欲素B是下丘脑神经肽,通过激活两种G蛋白耦联受体发挥作用.增食欲素及其受体表达于下丘脑室旁核和正中隆起,增食欲素受体还表达于脑垂体促皮质激素细胞、肾上腺皮质和髓质.增食欲素能调节摄食、能量代谢平衡、睡醒周期、血压等,还能调节下丘脑-垂体-肾上腺(HPA)轴.现就增食欲素及其受体在HPA轴中枢支和周围支(peripheral branches)的表达及作用机制作一综述.
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| 关 键 词： | 增食欲素 增食欲素受体 下丘脑-垂体-肾上腺轴 |
Recent progress of orexin in the regulation of the hypothalamic-pituitary-adrenal axis |
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| WANG Lu,ZHAO Yu-yan. Recent progress of orexin in the regulation of the hypothalamic-pituitary-adrenal axis[J]. International JOurnal of Endocrinology and Metabolism, 2010, 30(1): 22-25. DOI: 10.3760/cma.j.issn.1673-4157.2010.s1.008 |
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| Authors: | WANG Lu ZHAO Yu-yan |
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| Abstract: | Orexin A and orexin B are hypothalamic peptides that play roles via two G protein-cou-pled receptors. Orexins and their receptors are expressed in the hypothalamic paraventricular nucleus and me-dian eminence, orexins receptors also expressed in pituitary corticotrophs, adrenal cortex and medulla. Orexins regulate feeding, energy metabolic homeostasis, the sleep/wake cycle, blood pressure and so on, they also modulate the hypothalamic-pituitary-adrenal (HPA) axis. Expression and function of orexins and their recep-tors in the central and peripheral branches of the HPA axis are reviewed in this article. |
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| Keywords: | OrexinOrexin receptorsHypothalamic-pituitary-adrenal axis |
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