| 茶多酚的表遗传机制与肿瘤防治 |
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| 引用本文： | 倪娟,徐伟江,汪旭. 茶多酚的表遗传机制与肿瘤防治[J]. 国际遗传学杂志, 2010, 34(6): 107-112. DOI: 10.3760/cma.j.issn.1673-4386.2011.02.010 |
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| 作者姓名： | 倪娟 徐伟江 汪旭 |
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| 作者单位： | 650092,昆明,云南师范大学生命科学学院;生物能源持续开发与利用教育部工程研究中心; |
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| 基金项目： | 国家自然科学基金云南省社会发展基础研究计划云南省科技项目 |
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| 摘 要： | 茶多酚(tea polyphenols,TP)是绿茶中对人体有益的主要成分,其对多种不同类型的肿瘤发生可能具有防护作用,其中包括表遗传途径.表遗传指不改变DNA序列的情况下基因表达发生可遗传改变的机制,主要包括DNA甲基化、组蛋白修饰、染色质重塑、siRNA和miRNA调控等,在人类的大多数肿瘤中都观察到表修饰模式的异常.茶多酚具有抑制DNA甲基转移酶、改变组蛋白修饰和miRNA表达的生物学活性,对肿瘤的防护与治疗具有一定的价值.该文就茶多酚的表遗传机制的研究进展作一简要概述.
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| 关 键 词： | 茶多酚 表遗传 肿瘤防治 |
The epigenetic mechanism of tea polyphenols in tumor prevention |
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| NI Juan,XU Wei-jiang,WANG Xu. The epigenetic mechanism of tea polyphenols in tumor prevention[J]. International JOurnal of Genetics, 2010, 34(6): 107-112. DOI: 10.3760/cma.j.issn.1673-4386.2011.02.010 |
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| Authors: | NI Juan XU Wei-jiang WANG Xu |
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| Abstract: | Tea polyphenols (TP) is one of components from green teas, beneficial to human health. They may help prevent different types of tumors, and are involved in epigenetic pathway. Epigenetics is defined as reversible heritable changes in gene expression that occur without alteration in DNA sequence, including DNA methylation, histone modification, chromatin remodeling, and RNA interference.Most of tumors in humans have shown the abnormal patterns of epigenetics. Tea polyphenols demonstrated some effects of epigenetic agents, inducing epigenetic changes through modifying methylation, histone modifications and expression of some miRNAs. It has potential to be used as an agent for tunor prevention. |
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| Keywords: | Tea polyphenolsEpigeneticTumor prevention |
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