| Lipotoxicity and the function of pancreatic β cells |
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| 引用本文： | 王广宇,吴国亭.Lipotoxicity and the function of pancreatic β cells[J].国际内分泌代谢杂志,2010,30(1):36-38. |
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| 作者姓名： | 王广宇 吴国亭 |
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| 作者单位： | 同济大学附属第十人民医院内分泌科,上海,200072; |
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| 基金项目： | 上海市科委科技攻关重大项目 |
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| 摘 要： | Type 2 diabetes mellitus often companied with dyslipidemia. Lipotoxicity contributes to β cell dysfunction and apoptosis through a variety of ways and factors, such as ceramidc, protein kinase family, oxidative stress, caspase family, endoplasmic reticulum stress, peroxisome proliferator-activated receptor, etc. This article reviews the relationship between 13 cells and lipotoxicity,and its mechanism.
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| 关 键 词： | 2型糖尿病 脂毒性 β细胞 细胞凋亡 β cell |
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