| 噻唑烷二酮类药物肾脏保护作用研究进展 |
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| 引用本文： | 殷汉,孙子林,王尧. 噻唑烷二酮类药物肾脏保护作用研究进展[J]. 国际内分泌代谢杂志, 2010, 30(1): 55-58. DOI: 10.3760/cma.j.issn.1673-4157.2010.s1.020 |
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| 作者姓名： | 殷汉 孙子林 王尧 |
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| 作者单位： | 东南大学中大医院内分泌科,南京,210009; |
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| 摘 要： | Thiazolidinediones (TZDs) --peroxisome proliferators activated receptor (PPAR)γ activa-tor,are a class of antidiabetic drugs for type 2 diabetes mellitus through their insulin sensitizing action. Stud-ies have shown that PPARγ lies in intercapillary cell, tubular cell and podocyte, etc. More and more animal and clinic evidences support the concept that TZDs can delay renal failure and have a directly protective effect against kidney by several mechanisms ,such as improving kidney hacmodynamics and endothelium func-tion, inhibiting glycosylation,anti-inflammatiou, reduction of oxidative stress, etc. In addition, these effects are independent of lowing hyperglycacmia, hypedipemia and hypetinsulinism. TZDs provide new concept and method in treating diabetic nephropathy and other chronic kidney diseases.
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| 关 键 词： | 噻唑烷二酮类药物 糖尿病 糖尿病肾病 肾脏 |
Effects of thiazolidinediones on protection of the kidney |
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| YIN Han,SUN Zi-lin,WANG Yao. Effects of thiazolidinediones on protection of the kidney[J]. International JOurnal of Endocrinology and Metabolism, 2010, 30(1): 55-58. DOI: 10.3760/cma.j.issn.1673-4157.2010.s1.020 |
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| Authors: | YIN Han SUN Zi-lin WANG Yao |
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| Abstract: | |
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| Keywords: | ThiazolidinedionesDiabetes mellitusDiabetic nephropathyKidney |
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