2型糖尿病大鼠胰腺微区血液灌流量与空腹血糖的相关性研究

Objective To observe the dynamic change of microcirculatory hemoperfusion in pancreatic head,body and tail of type 2 diabetic rats and its relationship with fasting blood glucose.Method All Wistar rats were randomly divided into control group(n=130)and experimental group(n=150).The rat model of type 2 diabetes mellitus was established by high-fat,high-sugar feeding combined with low-dose streptozotocin(30 mg/kg).At the 0,4,8,12,16 weeks after the occurrence of diabetes,twenty rats were picked up randomly and respectively from two groups,and microcirculatory hemoperfusion in pancreatic head,body and tail and fasting blood slucose were measured in vivo.Results At the 0,4,8,12,16 weeks after the occurrence of diabetes,fasting blood glucose in experimental group were(10.25±7.98),(14.72±7.51),(19.23±6.09),(22.44±7.45),(26.03±4.96)mmol/L respectively,while microcirculatory hemoperfusion in pancreatic body and tail were(2.46±0.90),(2.79±1.34),(3.15 ±1.24),(3.76±0.99),(4.28±0.23)V respectively.They both increased progressively(P<0.05).No significant changes were found in pancreatic head compared with control group(P>0.05). Microcirculatory hemoperfusion in pancreatic body and tail was positively associated with fasting blood glucose(r=0.3786,P<0.05).Conclusion Microcirculatory hemoperfusion in pancreatic body and tail increased with the increase of fasting blood glu cose in type 2 diabetic rats.

Relationship of microcirculatory hemoperfusion in pancreas and fasting blood glucose of type 2 diabelie rats