| MTNR1B基因多态性与2型糖尿病 |
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| 引用本文： | 胡敬,季虹,荣海钦. MTNR1B基因多态性与2型糖尿病[J]. 国际遗传学杂志, 2010, 33(2): 306-309. DOI: 10.3760/cma.j.issn.1673-4386.2010.05.012 |
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| 作者姓名： | 胡敬 季虹 荣海钦 |
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| 作者单位： | 山东省内分泌与代谢病研究所,济南,250062; |
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| 摘 要： | 2型糖尿病是一种与多基因、多因素相关联的具有明显遗传异质性的疾病.全基因组关联分析显示MTNR1B基因变异与胰岛素分泌、葡萄糖水平以及2型糖尿病发病有显著相关性.MTNR1B基因是2型糖尿病重要的易感基因之一,其变异可能通过减少β细胞胰岛素分泌,从而增加2型糖尿病的易感性.
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| 关 键 词： | 基因多态性 2型糖尿病 |
The polymorphisms of MTNR1B gene and type 2 diabetes mellitus |
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| HU Jing,JI Hong,RONG Hai-qin. The polymorphisms of MTNR1B gene and type 2 diabetes mellitus[J]. International JOurnal of Genetics, 2010, 33(2): 306-309. DOI: 10.3760/cma.j.issn.1673-4386.2010.05.012 |
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| Authors: | HU Jing JI Hong RONG Hai-qin |
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| Abstract: | Type 2 diabetes mellitus is a genetically heterogeneous disease associated simultaneously with various environmental factors. Genome-wide association studies have shown that variation in MTNR1B is associated with insulin secretion, glucose concentration and the T2DM incidence. MTNR1B is one of the important T2DM-susceptibility genes. The variations of the gene increase a risk of type 2 diabetes mellitus possibly by decreasing Beta-cell insulin secretion. |
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| Keywords: | MTNR1BMTNR1BGene polymorphismsType 2 diabetes mellitus |
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