乳化异氟烷器官保护作用研究进展

Background Emulsified isoflurane (EI) is a new type of anesthetic which is still not clinically available. It consists of isoflurane and 30% of fat emulsion as carrier, which can provide good anesthetic effect. Both in vitro and in vivo animal studies have demonstrated that pre-or post-conditioning with EI can produce protective effects for many organs. Purpose To review organ protective effects and the mechanisms of pre- or post-conditioning with EI. Content It is demonstrated that, both in vitro and in vivo animal studies, pre- or post-conditioning with EI can produce protective effects on heart, lung, brain and liver from ischemia reperfusion injuries within a certain range of concentration. And it is supposed that these effects are resulted from isoflurane itself. The mechanisms involve the activation of ATP-sensitive potassium channels, inhibition of NF-κB activation, inhibition of apoptosis and anti-oxidation, etc. Trend As a new intravenous formulation, EI will have a better clinical application for vital organs protection. But all the studies at present only focused on animal experiments, much more further studies need to be done before it can be applied in the clinic.

Advance in organ protective effects of emulsified isoflurane