支气管动脉灌注化疗及支气管动脉、肺动脉双介入治疗肺癌的疗效对比研究

目的：观察支气管动脉灌注化疗及支气管动脉、肺动脉双介入治疗肺癌的临床疗效，探讨其临床价值。方法选择2008年3月-2010年3月在本院诊治的肺癌患者80例为研究对象，将患者分成观察组和对照组，每组40例，对照组行支气管动脉灌注化疗，观察组行支气管动脉和肺动脉双介入治疗，比较两组患者治疗效果。结果观察组1-3年生存率分别为70.0%、52.5%、25.0%，对照组1-3年生存率分别为72.5%、50.5%、22.5%，两组患者1-3年生存率比较，差异无统计学意义（ P﹥0.05）；观察组和对照组3年平均生存时间分别为（26.8±12.5）个月、（25.4±12.8）个月，差异无统计学意义（ P﹥0.05）。结论支气管动脉和肺动脉双介入治疗肺癌未见显著疗效，相比支气管动脉单介入治疗方法，其不仅增加临床用药量，导致临床毒副作用增强，同时加大了临床治疗的难度，不利于保护患者的切身利益。

Effect Comparison of Bronchial Artery Infusion Chemotherapy and Bronchial Artery and Pulmonary Artery Double Step in the Treatment of Lung Cancer

Objective To observe the curative effect of bronchial artery infusion chemotherapy and bronchial artery and pulmonary artery double step in the treatment of lung cancer,to explore its clinical value. Methods 80 cases with lung cancer diagnosed and treated in our hospital from March 2008 to March 2010,which were divided into observation group and control group,40 cases in each group. Control group was treated with bronchial artery infusion chemotherapy,observation group was treated with bronchial artery and pulmonary artery double step,curative effect of the two groups were compared. Results 1 to 3-year survival rate of observation group were 70. 0%,52. 5%,25. 0%,1 to 3-year survival rate of control group were 72. 5%,50. 5%,22. 5%,the differences were not statistically significant（ P﹥0. 05）;3 year average survival time of obser-vation group and control group were（26. 8 ± 12. 5）months,（25. 4 ± 12. 8）months,the difference was not statistically significant（ P﹥0. 05）. Conclusion The curative effect of bronchial artery and pulmonary artery double step in the treatment of lung cancer was not remarkable,compared with bronchial artery interventional therapy alone,which not only increases the amount of clinical medicine,resulting in enhanced clinical side effects,while increasing the difficulty of clinical treatment,is not conducive to the protection of the patient′s vital interests.