甲基强的松龙鞘内注射治疗急性期多发性硬化的疗效观察

目的：探讨甲基强的松龙鞘内注射治疗急性期多发性硬化的临床疗效，以指导临床治疗。方法选择2008年1月-2013年1月收治的急性期多发性硬化的患者74例，随机分为对照组与观察组各37例，对照组予甲基强的松龙静脉滴注，观察组予甲基强的松龙鞘内注射，观察、对比2组临床疗效。结果观察组治疗优良率为91.89%明显高于对照组的78.38%，2组比较差异有统计学意义（P ﹤0.05）；2组治疗后均未出现明显肝、肾功能损害等严重不良反应。结论甲基强的松龙鞘内注射治疗急性期多发性硬化的临床疗效显著，能够较快的促进患者神经功能的恢复，值得临床广泛推广。

Effect observation of methylprednisolone intrathecal injection in the treatment of acute phase multiple sclerosis

Objective To investigate the clinical efficacy of methylprednisolone intrathecal injection in the treatment of acute phase multiple sclerosis,in order to guide the clinical treatment. Methods 74 cases of patients admitted to our hos-pital from January 2008 to January 2013 were randomly divided into control group and observation group,each of 37 cases. The control group was given intravenous infusion of methylprednisolone,while the observation group was given intrathecal injection of methylprednisolone. The clinical efficacy of 2 groups was compared. Results The excellent rate of observation group （91. 89% ）was higher than that of control group（78. 38% ）,the difference was statistically significant（P ﹤ 0. 05）. Both groups had not serious adverse reactions after treatment. Conclusion methylprednisolone has a significant effect in the intrathecal in-jection of acute phase multiple sclerosis,which is worthy of clinical application.