盐酸氨溴索不同给药方式辅助治疗小儿肺炎的临床效果观察

目的：比较盐酸氨溴索不同给药方式辅助治疗小儿肺炎的临床效果。方法收集2012年8月-2013年12月医院治疗的小儿肺炎患儿180例，按照随机数字表法分为4组：A 组、B 组、C 组、D 组各45例。所有患儿均给予基础综合治疗，在此基础上，A 组口服盐酸氨溴索治疗，B 组采用盐酸氨溴索静脉给药治疗，C 组采用盐酸氨溴索雾化吸入给药治疗，D 组不给于盐酸氨溴索治疗。结果 A 组、B 组、C 组临床症状、体征消失时间及住院时间均明显短于 D 组，差异有统计学意义（P ﹤0.05）；C 组咳嗽消失时间、肺部啰音消失时间、胸部 X 线片恢复正常时间、住院均明显短于 A 组、B 组，差异有统计学意义（P ﹤0.05）。A 组、B 组、C 组显效率及总有效率均明显高于 D 组，差异有统计学意义（P ﹤0.05）；C 组显效率明显高于 A 组、B 组，差异有统计学意义（P ﹤0.05）。结论采用盐酸氨溴索雾化吸入治疗小儿肺炎效果较好，安全性高，可以在临床推广应用。

Clinical effect of different administration mode of ambroxol hydrochloride in the adjuvant treatment of infantile pneu-monia

Objective To compare the clinical results of different ambroxol hydrochloride administration mode in the adjuvant treatment of infantile pneumonia. Methods 180 cases of children with pneumonia were selected from August 2012 to December 2013 in our hospital and randomly divided into four groups：Group A,Group B,Group C,group D,each of 45 cases. All patients were given with basic therapy. The group A were oral ambroxol hydrochloride for treatment,group B received intra-venous therapy with ambroxol hydrochloride,group C received aerosol inhalation treatment with ambroxol inhalation,group D did not given ambroxol hydrochloride. Results The clinical symptoms and signs disappear time and hospital stay of group A, Group B and Group C were significantly shorter than in the group D,the difference was statistically significant（P ﹤ 0. 05）;The cough disappeared time,pulmonary rales disappeared time,chest X-ray recovery time,hospital stay time of Group C were signif-icantly shorter than in group A,group B,the difference was statistically significant（P ﹤ 0. 05）. The efficient rate and the total effective rate of group A,group B,group C were significantly higher than the group D,the difference was statistically significant （P ﹤ 0. 05）,and the group C was significantly higher than group A,group B,the difference was statistically significant（P ﹤0. 05）. Conclusion The aerosol inhalation treatment with ambroxol inhalation for infantile pneumonia has good curative effect,with higher security,which can be used in clinical practice.