急性心肌梗死患者血浆蛋白的相关研究

目的 探讨血浆白蛋白（A）、球蛋白（G）、纤维蛋白原（Fg）水平和白蛋白/球蛋白比值（A/G值）与急性心肌梗死（AMI）的相关性.方法 选择98例AMI患者,并设立对照组,同时检测血浆白蛋白、球蛋白和纤维蛋白原水平,记录高血压、2型糖尿病、高脂血症等病史和吸烟史,比较AMI组与对照组各指标间的差异,在排除年龄、性别、高血压、2型糖尿病等因素的影响后,用逻辑回归来分析相关危险因素对AMI的作用大小.结果 AMI组的白蛋白、球蛋白、纤维蛋白原和A/G值与对照组相比差异有统计学意义（P〈0.05）;Logistic回归分析显示,白蛋白、纤维蛋白原、A/G值与AMI的发生有关.结论 AMI患者白蛋白、A/G水平明显降低,球蛋白和纤维蛋白原水平明显增高.低白蛋白、A/G及高纤维蛋白原与AMI发生有关.

The study of the changes of the serum protien in patients with acute myocardial infarction

Objective To Study the relativity of the albumin, globin, fibrinogen and A/G levels in serum with acute myocardial infarction （AMI）. Methods The levels of albumin, globin, fibrinogen and A/G in serum were assayed in 98 cases of acute myocardial infarction and 98 normal persons. Hypertension, diabetes mel- litus, hyperlipemia and cigarette smoking were observed and compared at the same time. After exclusion the influ- ences of age, sex, hypertension, type 2 diabetes, the risk factors of AMI were analyzed using logistic regression. Results （1）Compared the levels of albumin, globin, fibrinogen and A/G in serum, the acute myocardial infarc- tion group had difference with normal eontrols （P=0.013,P=0.022,P〈0.001,P〈0.001）. （2）The logistic regression analysis showed that the occur of AMI related with sex, albumin, globin, fibrinogen, A/G, hypertension, diabetes mellitus and hyperlipemia.Conclusion The levels of albumin and A/G in serum may relate with oeeur of AMI, when the levels of glabin and fibrinogen were obvious rised. The levels of albumin, A/G are significantly lower in AMI patients, and globulin and fibfinogen levels are signifieantly inereased. Low albumin, A/G and high fibrino- gen levels may relate with the occurrence of AMI.