正已烷多发性周围神经损伤早期指标的调查

目的:探讨正已烷对多发性周围神经损伤的早期影响。方法:160例正己烷产业工人作为研究对象被随机分为实验组(直接接触者)和对照组(非直接接触者),调查两组的作业场所正己烷浓度(采用TWA浓度)、尿中2,5-己二酮浓度、神经行为功能(采用NCTB)和情感功能状态(采用SCL-90)。结果:(1)TWA浓度平均值为(32.54±38.75)mg/m~3。监测点TWA合格率为80%。(2)实验组2,5-己二酮浓度范围为(0.50～5.34)mg/L,对照组为(0.13～0.47)mg/L。两组比较统计学差异具有显著性(t=7.43,P<0.01)。(3)实验组NCTB手提转捷度、简单反应时、目标追踪测试等指标显著差于对照组(P<0.05)(4)实验组SCL-90总分和抑郁、焦虑、躯体化等3组因子得分均显著高于对照组(P<0.05)。结论:正已烷多发性周围神经指标的检测对于预防中毒具有重要意义,但由于正己烷导致的毒性问题有其深刻的社会性,需要各方面的共同努力。

The Survey of Early Index of Multiple Peripheral Nerve Injury Caused by n-Hexane

Objective:To explore the influence of n-hexane on multiple of peripheral nerve injury.Methods:160 cases of n-hexane related worker were randomly divided into experimental group(direct toucher) and control group(indirect toucher). Both groups were detected with such indexes:TWA concentration of n-hexane,concentration of 2,5-hexanedione in urine,NCTB and SCL-90.Results:(1) The average TWA concentration was(32.54±38.75)mg/m~3,passed rate of monitoring point was 80%.(2) The concentration of 2,5-hexanedione in experimental group was(0.50～5.34)mg/L,and in control group was(0.13～0.47)mg/L,there was significant difference between two group(t=7.43,P<0.01).(3) Many indexes of NCTB in experimental group was significant worse than control group(P<0.05).(4) Total score and some indexes of SCL-90 in experimental group was significant higher than control group (P<0.05).Conclusion:Detection of early index of multiple of peripheral nerve injury caused by n-hexane is important on prevention of poisoning,but because of profound sociality about this problem,it needs commonly hard work from various directions