妊娠期高血压疾病患者血清白细胞介素-18和胎盘生长因子水平变化及意义

目的:探讨妊娠期高血压疾病患者血清白细胞介素-18和胎盘生长因子水平变化及意义。方法:采用酶联免疫吸附分析法测定实验组60例妊娠高血压疾病患者(妊娠期高血压20例,轻度子痫前期20例,重度子痫前期20例)和正常晚期妊娠孕妇(对照组)35例血清IL-18及sFlt-1水平并进行比较,绘制ROC曲线观察其对妊娠期高血压疾病的诊断价值。结果:实验组患者血清IL-18及sFlt-1水平明显高于对照组;同时,轻度子痫前期、重度子痫前期患者的血清IL-18及sFlt-1水平明显高于妊娠期高血压患者;重度子痫前期患者的血清IL-18及sFlt-1水平明显高于轻度子痫前期患者;ROC曲线分析血清IL-18及sFlt-1的诊断特性最好。结论:妊娠期高血压疾病患者血清IL-18及sFlt-1的水平变化在一定程度上反应病情的轻重,可做为联合诊断和病情评估的重要指标。

The Changes of Serum Interleukin-18 (IL-18) Level and Placentga Growth Factor(PLGF) and Its Significance in Patients with Hypertensive Disorder Complicating Pregnancy

Objective:To study the changes of serum interleukin-18(IL-18)level and placentga growth factor(PLGF)and its clinical significance in patients with hypertensive disorder complicating pregnancy.Methods:Serum concentrations of interleukin-18 and Human soluble vascular endomelial growth factor receptor 1(sFlt-1)were measured in 60 patients with hypertensive disorder complicating pregnancy by enzyme-linkedimmunosorbentassay(ELISA)(20 patients with hypertensive disorder complicating pregnancy,20 moderate preeclampsia-eclampsia and 20 severe preeclampsia-eclampsia)and 35 cases of normal late pregnancies drawing ROC curve and oberseving the diagnostic value of ROC curve in hypertensive disorder complicating pregnancy by enzyme-linkedimmunosorbentassay (ELISA).Results:Mean serum IL-18 and sFlt-1 levels of the experimental group were significantly higher than the control group and the serum IL-18 and sFlt-1 levels of patients of moderate preeclampsia-eclampsia and severe preeclampsia-eclampsia were significantly higher than the patients with hypertensive disorder complicating pregnancy.Mean serum IL-18 and sFlt-1 levels of patients of severe preeclampsia-eclampsia was significantly higher than the patients of moderate preeclampsia-eclampsia.It was the best to diagnosize the Mean serum IL-18 and sFlt-1 levels by ROC curve.Conclusion: the changes of serum IL-18 and sFlt-1 levels of patients with hypertensive disorder complicating pregnancy reflects the severity of diseases in some extent and may be closely related to combining diagnosis and evaluation of the state of disease.