基质金属蛋白酶2和9在乳腺癌中的表达及临床意义

目的:探讨基质金属蛋白酶2(MMP2)和MMP9在乳腺癌中的表达及其与侵袭、淋巴结转移及预后的关系。方法:用免疫组化检测130例乳腺癌组织和10例乳腺良性病变组织中MMP2和MMP9表达。结果:在130例乳腺癌组织中,MMP2和MMP9阳性表达率分别为83.08%(108/130)和71.54%(93/130),明显高于乳腺良性病(P<0.01),且随肿块大小,临床分期的增加呈明显升高趋势,差异有统计学意义。腋下淋巴结转移组中MMP2和MMP9的高表达明显高于无淋巴结转移组(P<0.01)。结论:乳腺癌中MMP2和MMP9的表达与淋巴结转移密切相关,可作为判断乳腺癌淋巴结转移和预后的指标。

The expression and Clinical Meaning of Matrix Metalloproteinase 2(MMP2),Matrix Metalloproteinase 9 (MMP9) in the Breast Cancer

Objective:To investigate the expression and the relationship with tumor invasive potential,node metastasis and prognostic significance of matrix metalloproteinase 2(MMP2),matrix metalloproteinase 9(MMP9)in the breast cancer.Methods:One hundred and thirty cases of breast cancer and ten cases of breast benign disease were studied by immunohistochemical staining with anti MMP2,MMP9 monoclonal antibodies.Results:The positive expression rate of MMP2 and MMP9 were 83.08%(108/130)and 71.54%(93/130)in the breast cancers,significantly higher than those in breast benign disease(P<0.01).The expressions of MMP2 and MMP9 were rise obviously with tumor sizes,clinical staging.Over expression of MMP2 and MMP9 in the breast cancers with axillary lymph node metastases was significantly higher than that without lymph node metastases(P<0.01).Conclusion:The expression of MMP2 and MMP9 closely correlated to lymph node metastasis,and act as lymph node metastasis prognostic markers for patients with breast cancer.