单唾液酸神经节苷脂注射液治疗新生儿缺氧缺血性脑病临床疗效观察

目的:探讨单唾液酸神经节苷脂注射液治疗新生儿缺氧缺血性脑病(HIE)的临床疗效和安全性。方法:随机选取我院2008年6月至2010年7月收治的120例缺氧缺血性脑病患儿,随机平均分为两组,对照组给予常规对症支持治疗(常规营养脑细胞药物胞二磷胆碱等),治疗组在此基础上加用神经节苷脂钠注射液静脉滴注。结果:治疗组和对照组分组治疗后总有效率分别为88.33%和71.67%,两组差异具有统计学意义(P<0.05)。结论:单唾液酸神经节苷脂钠治疗能有效控制因缺氧缺血所致的脑水肿,临床疗效确切有效,值得临床上进一步推广和应用。

ClinicaI Effect Observation of Monosialoganglioside on Neonatal Hypoxie-ischemic Encephalopathy

Objective:To observe the clinical effects and safety of monosialoganglioside on neonatal hypoxie-ischemic encephalopathy.Methods:120 cases from June 2008 to July 2010 of neonatal hypoxie-ischemic encephalopathy patients hospitalized in our hospital randomly divided into study group(60c eses)and the control group(60c eses).Control group received conventional symptomatic and supportive treatment(citicoline,and so on).Study group based on the treatment of control group,add monosialoganglioside intravenously guttae.Results:There were statistical differences between the study group(88.33%) and control group(71.67%) in effective rate(P<0.05).Conclusion:Monosialoganglioside effectively control the sodium in the treatment caused by hypoxic ischemic brain edema. The clinical effects were exactive and effective.It was worth of further promotion and application.