Distribution of <span style="font-variant: small-caps">d</span>-amino acid oxidase (DAO) activity in the medulla and thoracic spinal cord of the rat: implications for a role for <span style="font-variant: small-caps">d</span>-serine in autonomic function期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Distribution of d-amino acid oxidase (DAO) activity in the medulla and thoracic spinal cord of the rat: implications for a role for d-serine in autonomic function

Authors:	Ranjna Kapoor Vimal Kapoor

Affiliation:	School of Physiology and Pharmacology, University of New South Wales, Sydney, NSW 2052, Australia

Abstract:	The activity and regional distribution of Full-size image -amino acid oxidase (DAO), an enzyme that inactivates Full-size image -serine, were examined in the medulla and spinal cord of the rat by biochemical and histochemical procedures. DAO activity was noticeably low or absent in the nucleus of the solitary tract, ventrolateral medulla and intramediolateral cell column of the spinal cord. This may be indicative of a neuromodulatory role for endogenous Full-size image -serine (at the NMDA-glycine site) in the central control of blood pressure.

Keywords:	sizeImgBox" > sizeImgLink" >Full-size image -Serine sizeImgBox" > sizeImgLink" >Full-size image -Amino acid oxidase NMDA-glycine site Nucleus of the solitary tract Ventrolateral medulla Intramediolateral cell column Blood pressure regulation
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