生黄合剂对病毒性心肌炎小鼠血清SOD活性和MDA含量的影响

目的：观察生黄合剂对病毒性心肌炎小鼠血清超氧化物歧化酶（SOD）活性和丙二醛（MDA）含量的影响。方法：雄性Balb/cd,鼠随机分为4组：生黄合剂组（注射CVB3后灌胃给与生黄合剂），抗病毒口服液组（注射CVB3后灌胃给与抗病毒口服液）、病毒组（仅注射CVB3）和正常组；分别采用黄嘌呤氧化酶法和硫代巴比妥酸法检测各组小鼠血清SOD活性和MDA含量。结果：给药后第10d，生黄合剂组小鼠的生存率明显高于病毒对照组和抗病毒口服液组（P〈0．01）；生黄合剂可明显提高病毒性心肌炎小鼠血清中SOD活性和降低MDA含量（P〈0．01），且效果优于抗病毒口服液（P〈0．01）。结论：生黄合剂可提高病毒性心肌炎小鼠的抗氧化能力，对病毒性心肌炎有一定的治疗作用。

EFFECTS OF SHENG-HUANG COMPOSITION ON SOD ACTIVITY AND MDA CONTENT IN SERUM OF VIRAL MYOCARDITIS MICE

Objective：To observe the effects of Sheng-huang composition on SOD activity and MDA content in serum of viral myocarditis mice.Methods：Male Balb/c male mice were randomly divided into 4 groups： Sheng-huang composition group （intragastric administration Sheng-huang composition after injecting CVB3）, Kangbingdukoufuye group （intragastric administration Kangbingdukoufuye after injecting CVB3）,virus group （only injecting CVB3） and normal group.The SOD activity and MDA content in serum of mice in each group were detected.Results： 10 days after administration, the survival rate of mice in Sheng-huang composition group was obviously higher than virus group and Kangbingdukoufuye group （P 〈 0.01）;Sheng-huang composition can significantly increase SOD activity and decrease MDA content in serum of viral myocarditis mice （P 〈 0.01）;moreover,the effects of Sheng-huang composition was significantly better than Kangbingdukoufuye （P 〈 0.01）.Conclusions：Sheng-huang composition can increase the anti-oxidative ability of viral myocarditis mice and has fairly therapeutical effects on viral myocarditis.