阿立哌唑治疗精神分裂症老年患者临床疗效观察

目的]研究阿立哌唑治疗精神分裂症老年患者的临床疗效和不良反应,为临床提供依据。方法]选择符合CCMD-3精神分裂症诊断标准、简明精神疾病评定量表(BPRS)﹥35分、年龄≥65岁的病例共60例。随机分为阿立哌唑组与奋乃静组各30例。治疗前及治疗8周后分别用简明精神病评定量表(BPRS)及阳性和阴性综合征量表(PANSS)评定疗效,用副反应量表(TESS)评定不良反应。结果]阿立哌唑在治疗精神分裂症老年患者总疗效和对情感障碍、意志障碍的改善明显优于奋乃静。阿立哌唑在行为毒性、神经系和植物神经系的副作用明显低于奋乃静。阿立哌唑副反应轻且相对安全、依从性高。结论]阿立哌唑治疗精神分裂症老年患者效果确切、安全性强、依从性高,能全面提高患者生活质量。

OBSERVATION ON THE CLINIC EFFICACY OF ARIPIPRAZOLE IN THE TREATMENT OF THE ELDERLY PATIENTS WITH SCHIZOPHRENIA

Objective]To study the efficacy and side effect of aripiprazole in the treatment of the elderly patients with schizophrenia,and to provide the basis for the clinical.Methods]According to CCMD-3,65 patients with BPRS score over 35 and aged above 60 years old were selected and randomly divided into two groups:30 patients had been given aripiprazole for 8 weeks,and 30 patients had been given perphenazine for 8 weeks,then all patients were assessed by BPRS,PANSS and TESS.Results]Both aripiprazole and perphen...