Complete remission of generalized relapsed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type of the gastrointestinal tract after high-dose chemotherapy and autologous peripheral stem cell transplantation |
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| Authors: | P. Neumeister G. Hoefler C. Beham-Schmid H. Sill W. Linkesch |
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| Affiliation: | (1) Division of Hematology, Department of Medicine and Karl-Franzens-University, Graz, Austria, AT;(2) Institute of Cancer Genetics, Columbia University, 1150 St Nicholas St, Room 303, New York, N.Y. U-10032, USA e-mail: peter.neumeister@gmx.at Tel.: +1-212-3047381 Fax: +1-212-3045537, US;(3) Institute of Pathology, Karl-Franzens-University, Graz, Austria, AT |
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| Abstract: | Due to their homing properties, extranodal marginal zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid tissue (MALT) type remain localized for long periods of time, and therefore have an excellent prognosis. However, if generalization and/or transformation into a diffuse large-cell lymphoma occurs, the prognosis deteriorates and no established treatment concepts are yet available. We report about a 57-year-old female patient with relapsed transformed stage-IV extranodal MZBL of MALT type of the entire gastrointestinal tract who was successfully treated using salvage chemotherapy followed by BEAM conditioning [BCNU 1,3-bis-2-(chloroethyl-1-nitrosourea), etoposide, cytosine arabinoside, and melphalan] and autologous peripheral stem cell transplantation. Follow-up revealed a sustained complete remission for 22 months. Received: 14 October 1999 / Accepted: 28 March 2000 |
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| Keywords: | BEAM Mucosa-associated lymphoid tissue Marginal zone B-cell lymphoma |
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