Prospective prenatal serum screening for Down syndrome in Venezuela |
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Authors: | Francisco Alvarez-Nava Marisol Soto Alisandra Morales-Machín Alicia Rojas Karelis Urdaneta Jenny Ca?izález |
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Affiliation: | Unidad de Genética Médica, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela. falvareznava@yahoo.com |
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Abstract: | OBJECTIVE: To assess the usefulness of triple-marker screening for Down syndrome in Venezuela. METHOD: Maternal serum concentrations of alpha fetoprotein (AFP), beta human chorionic gonadotropin (beta-hCG), and unconjugated estriol (uE3) were measured weekly in 3895 women from the 15th to the 20th week of pregnancy. Population-specific likelihood ratios were determined and used to calculate the risk of fetal Down syndrome for each pregnancy. RESULTS: The median multiple of the median values for AFP, beta-hCG, and uE3 concentrations were 0.69, 2.10, and 0.67 for the affected pregnancies. The likelihood ratio for a positive result was 1:19. The detection and false-positive rates were 69.23% and 5.8%. CONCLUSION: These findings were consistent with reported data and therefore confirmed triple-marker serum screening as effective and suitable for prenatal care in Venezuela. Latin American governments and Health Agencies should recommend offering this screening method to all pregnant women. |
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Keywords: | Fetal Down syndrome Prenatal diagnosis Prospective study Risk estimate Second-trimester maternal serum screening |
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