| 阿托伐他汀对血脂正常兔急性心肌梗死再灌注后梗死范围的影响 |
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| 引用本文： | 丁超,傅向华,李俊峡,陈会校,李洁,杨莉,李淑荣,梅静.阿托伐他汀对血脂正常兔急性心肌梗死再灌注后梗死范围的影响[J].中国心血管病研究杂志,2008,6(10). |
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| 作者姓名： | 丁超 傅向华 李俊峡 陈会校 李洁 杨莉 李淑荣 梅静 |
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| 作者单位： | 解放军白求恩国际和平医院心血管内科;河北医科大学第二医院干部病房心内科; |
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| 摘 要： | 目的 探讨阿托伐他汀预处理对急性心肌梗死后再灌注损伤的保护作用及作用机制.方法 采用结扎冠状动脉左前降支3 h后再开放60 min的方法,建立兔急性心肌梗死再灌注模型.20只兔随机分为4组:A组,急性心肌梗死再灌注组;B组,阿托伐他汀 急性心肌梗死再灌注组;C组,格列苯脲 急性心肌梗死再灌注组;D组,格列苯脲 阿托伐他汀 急性心肌梗死再灌注组.再灌注后测定各组血清CK-MB活性,应用20%伊文氏蓝及1%氯化三苯四唑啉染色后计算心肌梗死面积.结果 B组心肌梗死面积及CK-MB活性较A组和C组显著减少(P<0.01),C组与A组相似(P>0.05),D组较A组显著减小(P<0.05),但仍明显高于B组(P<0.05).结论 阿托伐他汀可明显减小心肌梗死面积,对急性心肌梗死再灌注损伤具有保护作用,这可能与阿托伐他汀激活ATP敏感性钾通道有关.
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| 关 键 词： | 心肌梗死 阿托伐他汀 再灌注损伤 格列本脲 ATP敏感性钾通道 |
Effects of pretreatment with atorvastatin on the area of myocardial infarction in reperfusion normocholesterolemic rabbits after acute myocardial infarction |
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| DING Chao,FU Xiang-hua,LI Jun-xia,et al..Effects of pretreatment with atorvastatin on the area of myocardial infarction in reperfusion normocholesterolemic rabbits after acute myocardial infarction[J].Chinese Journal of Cardiovascular Review,2008,6(10). |
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| Authors: | DING Chao FU Xiang-hua LI Jun-xia |
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| Institution: | DING Chao,FU Xiang-hua,LI Jun-xia,et al. Department of Cardiology,Bethune International Peace Hospital of PLA,Shijiazhuang 050082,China |
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| Abstract: | Objective To investigate the effect s and mechanism of the pretreatment with atorvastatin on the area of myocardial infarction in reperfusion injury rabbits after acute myocardial infarction(AMI). Methods Twenty New Zealand white rabbits were randomly divided into four groups:group A, AMI/reperfusion, group B, treated with atorvastatin( 5 mg/kg) before AMI,group C, treated with glibenclamide(5 mg/kg) before AMI, group D,treated with glibenclamide and atorvastatin before AMI. Models of AMI/reperfusion were e... |
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| Keywords: | Myocardial infarction Atorvastatin Reperfusion injury Glibenclamide ATP-sensitive K channels |
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