| 竹节参总皂苷对脑缺血损伤大鼠海马一氧化氮合酶的影响 |
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| 引用本文： | 赵晖,张秋霞,穆阳.竹节参总皂苷对脑缺血损伤大鼠海马一氧化氮合酶的影响[J].中国中药杂志,2008,33(5):557-559. |
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| 作者姓名： | 赵晖 张秋霞 穆阳 |
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| 作者单位： | 1. 首都医科大学,中医药学院,北京,100069;北京中医药大学,中药学院,北京,100102
2. 首都医科大学,中医药学院,北京,100069 |
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| 基金项目： | 北京市优秀人才培养基金 |
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| 摘 要： | 目的:探讨竹节参总皂苷(tRPJS)对脑缺血损伤的保护作用机制,观察药物对局灶性脑缺血大鼠和慢性前脑缺血大鼠海马组织一氧化氮合酶(NOS)及诱导型一氧化氮合酶(iNOS)的影响。方法:采用线栓法建立局灶性脑缺血大鼠模型,双侧颈总动脉永久结扎方法制备慢性前脑缺血,研究竹节参总皂苷对这两种脑缺血损伤大鼠模型海马组织NOS,iNOS的影响。结果:与假手术组相比,局灶性脑缺血大鼠海马组织NOS,iNOS含量均明显增高(P<0.05),竹节参总皂苷能显著降低局灶性脑缺血大鼠NOS,iNOS的含量(P<0.05);慢性前脑缺血大鼠与假手术组相比,海马组织总NOS活力没有明显改变,iNOS含量增高(P<0.05),竹节参总皂苷能显著降低慢性前脑缺血大鼠海马组织iNOS的含量(P<0.05)。结论:竹节参总皂苷抗缺血性海马神经元损伤与降低海马组织iNOS的活性有关。
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| 关 键 词： | 竹节参总皂苷 脑缺血 一氧化氮合酶 |
| 文章编号： | 1001-5302(2008)05-0557-03 |
| 收稿时间： | 9/9/2007 12:00:00 AM |
| 修稿时间： | 2007年9月9日 |
Effects of total rhizoma panacis japonica saponins (tRPJS) on nitric oxide synthase in hippocampus region following rat ischemic cerebral injury |
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| ZHAO Hui ; ZHANG Qiu-xia ;MU Yang.Effects of total rhizoma panacis japonica saponins (tRPJS) on nitric oxide synthase in hippocampus region following rat ischemic cerebral injury[J].China Journal of Chinese Materia Medica,2008,33(5):557-559. |
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| Authors: | ZHAO Hui ; ZHANG Qiu-xia ;MU Yang |
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| Institution: | College of Traditional Chinese Medicine, Capital University of Medical Science, Beijing 100069, China. zhaohui8957@sina.com |
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| Abstract: | Objective:To observe the protective effects of total rhizoma panacis japonica saponins(tRPJS)on cerebral ischemia injury in rats.Method:The rat model of local cerebral ischemia by using thread method,produced the chronic forebrain ischemic by using the permanent occlusion of bilateral common carotid arteries in rats.Investigating the influence of tRPJS on the activity of NOS and iNOS in hippocampus region.Result:tRPJS obviously reduced the contents of NOS and iNOS in hippocampus region of local cerebral ischemia rat.tRPJS inhibited the increase of iNOS content caused by pemanent ligation of bilateral carotid artery.Conclusion:tRPJS has significantly protective effects by virtue of decreasing iNOS. |
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| Keywords: | total thizoma panacis japonica saponins(tRPJS) cerebral ischemia nitric oxide synthase |
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