奥拉西坦治疗老年脑梗死后认知功能障碍的临床研究

目的:探讨奥拉西坦治疗老年脑梗死后认知功能障碍的临床疗效。方法:将本院接收的112例老年脑梗死后认知功能障碍患者按照完全随机法均分为对照组和治疗组,对照组在常规治疗基础上给予吡拉西坦片,治疗组在常规治疗基础上给奥拉西坦胶囊,比较两组患者的认知功能、日常生活能力、不良反应发生状况。结果:两组患者治疗后的Mo CA评分、MMSE评分及Barthel指数均显著提高,治疗组Mo CA评分、MMSE评分及Barthel指数分别为(26.95±3.52)分、(28.11±1.21)分、(87.83±13.43)分,改善效果显著优于对照组(P<0.05);对照组和治疗组不良反应发生分别为3例和2例,差异无统计学意义(χ2=0.209,P>0.05)。结论:奥拉西坦治疗老年脑梗死后认知功能障碍的临床疗效显著,值得临床进一步推广。

Study on the clinical efficacy of oxiracetam on cognitive impairment after cerebral infarction

Objective:To discuss the clinical efficacy of oxiracetam in treatment of cognitive dysfunction after cerebral infarc-tion.Methods:1 12 cases of elderly patients with cognitive impairment after cerebral infarction received in our hospital were divided into control group and treatment group randomly,the patients of treatment group were given Piracetam Tablets on the basis of routine treat-ment,and the patients of treatment group were given oxiracetam capsules on the basis of routine treatment.cognitive function,daily the ability of life,adverse reaction condition of patients of the two groups were observed and compared.Results:MoCA score,MMSE score and Barthel index of patients of the two groups after treatment were significantly increased.MoCA score,MMSE score and Barthel index in treatment group were (26.95 +3.52),(28.1 1 +1 .21 )and (87.83 +13.43)respectively,better than the score in the control group significantly (P <0.05);the adverse reaction in the control group and the treatment group were 3 cases and 2 cases respectively,the difference was not statistically significant (χ2 =0.209,P >0.05).Conclusion:The clinical efficacy of oxiracetam in treatment of cogni-tive dysfunction after cerebral infarction is obvious,worthy of further promotion.