反复呼吸道感染患儿细胞免疫和血清免疫球蛋白、IgG亚类及水平分析

目的:探讨患儿反复呼吸道感染(RRTI)与细胞免疫和血清免疫球蛋白、Ig G亚类及水平相关性。方法:选取反复呼吸道感染患儿30例作为观察组,另择取健康体检儿童30名作为对照组,观察两组患儿血清免疫球蛋白、细胞免疫和Ig G亚类水平以及Ig G亚类在缺陷免疫球蛋白中的分布。结果:1观察组患儿Ig M明显低于对照组,差异有统计学意义(P<0.05);2观察组患儿Ig G2、Ig G4明显低于对照组,差异有统计学意义(P<0.05);3观察组检测出缺陷Ig G亚型共14例,占46.7%,其中单项缺陷8例,占所有Ig G亚型的57.1%,其中Ig G4为最主要亚型,占35.7%,其次为Ig G3,占14.3%;联合缺陷共6例,占42.9%,主要为Ig G2+Ig G4,占35.7%;4观察组患儿CD3、CD4水平明显低于对照组,差异有统计学意义(P<0.05)。结论:反复呼吸道感染患儿多为具有荚膜多糖成分的细菌导致,患儿多伴Ig M、Ig G2+Ig G4以及CD3+、CD4+T细胞的紊乱。

Cellular immunity and serum levels of immunoglobulin and IgG subclasses in children with recurrent respiratory tract infection

Objective:To investigate the correlation between and serum immunoglobulin,IgG subclasses and the level of serum immunoglobulin in children with recurrent respiratory tract infection (RRTI).Methods:30 children with recurrent respiratory tract in-fection were selected as observation group,the other 30 healthy children were selected as control group.Serum levels of immunoglobu-lin,cellular immunity,IgG subclasses and IgG subclasses in the two groups were observed.Results:IgM was significantly lower in the observation group than that in the control group (P <0.05);IgG2 and IgG4 were significantly lower in the observation group than thoes in the control group (P <0.05).In the observation group,there were 14 cases of IgG subtype,accounting for 46.7%.Among them,8 cases were single defects,which accounted for 57.1 % of all IgG subtypes,IgG4 being the most important subtype,accounting for 35. 7% (5 /14),followed by IgG3,accounting for 14.3% (2 /14);joint defects in a total of 6 cases,accounting for 42.9%,mainly for IgG2 +IgG4,accounting for 35.7% (5 /14).The observation group with CD3 and CD4 levels were significantly lower than those of the control group (P <0.05).Conclusion:Recurrent respiratory tract infection lead to the capsular polysaccharide of bacteria with c IgM, IgG2 +IgG4 and CD3 +,CD4 + T cell disorder in children.