HIV感染者外周血淋巴细胞总数与CD4+T淋巴细胞计数相关性研究

目的 分析HIV感染者外周血淋巴细胞总数(total lymphocyte count,TLC)与CD4+T淋巴细胞计数相关性,探讨将外周TLC作为监测HIV感染者病情变化指标的可行性.方法 回顾性分析我院54例HIV感染者TLC与CD4+T淋巴细胞计数相关性,判断CD4+T淋巴细胞计数分别＜100× 106/L、＜2...

Correlation between total lymphocyte count and CD4+ T lymphocyte count in patients with HIV infection

Objective To analyze the correlation between total lymphocyte count（TLC）and CD4＋ T lymphocyte count in pa-tients with HIV infection,and investigate the feasibility of using TLC instead of CD4^＋ T lymphocyte to estimate the status of HIV infection.Methods A retrospective study was conducted to analyze the correlation between TLC and CD4^＋ T lymphocyte count in 54 patients with HIV infection treated in our hospital.The corresponding critical value and accuracy of TLC were estimated when CD4＋ T lymphocyte counts were less than 100×10^6 /L,200×10^6 /L and 350×10^6 /L,and the sensitivity and specificity of each critical value were calculated.Results Ninety-six pairs of TLC and CD4^＋ T lymphocyte counts were positively correlated（r=0.642,P〈0.001）.TLC of 955×10^6 /L,1010×10^6 /L and 1570×10^6 /L could serve as critical values to estimate CD4^＋ T lymphocyte counts less than 100×10^6 /L,200×10^6 /L,and 350×10^6 /L with a great accuracy.Conclusion TLC can estimate the status of HIV infection instead of CD4^＋ T lymphocyte count.