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Airway response to acute mechanical stress in a human bronchial model of stretch |
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| Authors: | Christophe Faisy Francisco M Pinto Morgan Le Guen Emmanuel Naline Stanislas Grassin Delyle Edouard Sage Maria-Luz Candenas Philippe Devillier |
| Affiliation: | 1.Research Unit UPRES EA220, University Versailles-Saint-Quentin, Hôpital Foch, 40 rue Worth, Suresnes 92150, France;2.Medical Intensive Care Unit, European Georges Pompidou Hospital, 20 rue Leblanc, Paris Cedex 15, 75908, France;3.Instituto de Investigaciones Quimicas, CSIC, Av. Americo Vespucio, S/N. Isla De La Cartuja, Sevilla, 41092, Spain;4.Department of Thoracic Surgery, Hôpital Foch, 40 rue Worth, Suresnes, 92150, France |
| Abstract: | IntroductionLung inflation may have deleterious effects on the alveoli during mechanical ventilation. However, the consequences of stretch during excessive lung inflation on basal tone and responsiveness of human bronchi are unknown. This study was undertaken to devise an experimental model of acute mechanical stretch in isolated human bronchi and to investigate its effect on airway tone and responsiveness. |
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