地佐辛复合丙泊酚在无痛人工流产手术中的应用研究

目的 探讨地佐辛复合丙泊酚用于无痛人流手术中安全性和有效性。方法80例早孕女性，年龄18～36岁，随机分成2组（n=40）：A地佐辛组、B芬太尼组，分别复合丙泊酚静脉麻醉。观测用药前后患者生命体征变化及不良反应；记录患者意识消失及唤醒时间；观测术后15、30、60、120min疼痛、镇静及舒适度评分。结果 生命体征变化、不良反应、意识消失时间两组相比差异无统计学意义（P〉0．05）；但A组唤醒时间（8．3±1．6）min较B组（5．6±1．2）min长，差异有统计学意义（P〈0．05）；两组术后疼痛、舒适度评分在60，120min时间点比较差异有统计学意义（P〈0．0l或P〈0．05）。结论 地佐辛复合丙泊酚用于无痛人流是一种安全有效的麻醉方案。

Application of dezocine combined with propofol to painless induced abortion

Objective To evaluate the clinical efficacy and safety of using dezocine combined with propofol in outpatients undergoing painless induced abortion.Methods Eighty early pregnancy women aged 18-36 yr who voluntarily required painless induced abortion were randomly divided into 2 groups(n=40 each): Group A dezocine(0.1mg/kg),Group B fentanyl(1μg/kg),plus propofol through intravenous anesthesia respectively.The changes of vital sign and adverse reaction were assessed.The period of loss consciousness and arousal time were recorded.The scores of postoperative pain,consciousness-sedation,degree of comfort were registered at 15,30,60,120 min.Results Comparing the dezocine group with the fentanyl group,there was no significant difference in vital sign and adverse reaction at each time point.The arousal time in dezocine group was longer than that of fentanyl gronp(P<0.05).The VRS and BCS score showed significant difference at 60,120 min between the two groups(P<0.01 or P<0.05).No conspicuous adverse reactions postoperative were observed.Conclusion Application of dezocine combined with propofol to painless induced abortion is a safe and effective protocol.