胆汁细菌学检验及其对抗生素的耐药性分析

目的　了解胆道感染常见病原菌的种类及其对常用抗生素的耐药性 ,以指导临床合理用药。　方法　将 1998年 1月至 2 0 0 2年 6月间 6 9例住院病人胆汁培养阳性的 73株需氧菌及其对抗生素敏感性试验结果进行统计分析。　结果　标本的阳性检出率为 70 .4 % ,在分离株中 ,大多数病原菌为大肠埃希菌、肺炎克雷伯菌和肠球菌。革兰氏阴性杆菌对亚胺培南、阿米卡星和头孢他啶较为敏感 ,阳性球菌对万古霉素全部敏感。　结论　引起胆道感染的常见的需氧菌为大肠埃希菌、肺炎克雷伯菌和肠球菌 ,治疗时应根据药敏选择抗生素 ,必要时联合用药

Detection of biliary bacteria and analysis of drug resistance to antibiotics

Objective To investigate the species of the main pathogenic bacteria of biliary infection and their resistance rates to the commonly used antibiotics so as to instruct rational application of antibiotics clinically. Methods The data of 73 strains of aerobes found in 69 inpatients with positive bile culture from Jan 1998 to Jun 2002 and their sensitivity to antibiotics were statistically analyzed. Results The cultured positive rate in the specimens was 70.4%(69/98). Among the isolates,most of the pathogenic bacteria were Escherichia coli,Klebsiella pneumoniae and intestinal cocci. Imipenem,amikacin and ceftazidime are the relatively active against the gram negative bacillus,and all the gram positive cocci were sensitive to vancomycin. Conclusion The main pathogenicmicrobes of biliary infection were Escherichia coli,Klebsiella pneumoniae and intestinal cocci.In clinical therapy, sensitivity to antibiotics should selected based on the drug sensitive test,combined with other agents when necessary.