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| 肾络瘀阻证患者肾间质中α-SMA的表达及意义 | |
| 引用本文： | 杨东,杜永平,沈青,陈威,于艳,陈光磊.肾络瘀阻证患者肾间质中α-SMA的表达及意义[J].中西医结合学报,2008,6(1):41-44. |
| 作者姓名： | 杨东 杜永平 沈青 陈威 于艳 陈光磊 |
| 作者单位： | 1. 第四军医大学西京医院中医科,陕西西安,710032 2. 复旦大学儿科医院肾内科,上海,210000 3. 第四军医大学西京医院肾内科,陕西西安,710032 |
| 摘 要： | 目的：研究α平滑肌肌动蛋白（alpha—smoothmuscleactin，α-SMA）在肾络瘀阻证患者肾小管间质中的表达特征。方法：采用免疫组织化学法检测54例肾络瘀阻证患者肾穿刺标本中间质α-SMA的表达。结果：肾络瘀阻的程度与肾间质纤维化程度呈正相关（P〈0．01），并与间质中α-SMA的表达呈正相关（P〈0．01）。结论：肾络瘀阻是中医认识肾纤维化的病理本质之一，随着血瘀程度的加重，肾间质中肌成纤维细胞大量增殖，是导致肾间质纤维化的重要原因。 |
| 关 键 词： | 肾病 纤维化 α肌动蛋白 成纤维细胞 |
| 文章编号： | 1672-1977（2008）01-0041-04 |
Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis |
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| Dong YANG,Yon-gping DU,Qing SHEN,Wei CHEN,Yan YU,Guang-lei CHEN.Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis[J].Journal of Chinese Integrative Medicine,2008,6(1):41-44. | |
| Authors: | Dong YANG Yon-gping DU Qing SHEN Wei CHEN Yan YU Guang-lei CHEN |
| Institution: | Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shannxi Province 710032, China. |
| Abstract: | OBJECTIVE: To investigate the expression of alpha-smooth muscle action (alpha-SMA) in the renal tubulointerstitium in patients with kidney collateral stasis. METHODS: The expression of alpha-SMA in the renal biopsy specimens from 54 patients with kidney collateral stasis was examined by immunohistochemical method. RESULTS: The degree of kidney collateral stasis was increased with the increasing of the degree of renal interstitial fibrosis (P<0.05), and there was significant positive correlation between kidney collateral stasis and alpha-SMA expression (P<0.05). CONCLUSION: Kidney collateral stasis is one of the main reasons of renal fibrosis. With the increasing of kidney collateral stasis, MFBs in the renal interstitium proliferate obviously, becoming one of the most important causes of renal interstitial fibrosis. |
| Keywords: | nephrosis fibrosis alpha actin fibroblasts |
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