粒细胞-巨噬细胞集落刺激因子在新生儿肺炎中的变化

目的:检测粒细胞-巨噬细胞集落刺激因子(GM-CSF)在新生儿肺炎中的变化,与C反应蛋白(CRP)、中性粒细胞计数及血总胆红素的关系,为诊断细菌性新生儿肺炎提供可靠依据.方法:用放射免疫法检测23例新生儿肺炎血清GM-CSF,同时测定CRP、中性粒细胞计数、血总胆红素.结果:23例新生儿肺炎中GM-CSF阳性率60.89%,CRP阳性率13.04%,差异显著,P＜0.01.GM-CSF与中性粒细胞计数比较,存在正相关(P＜0.01),与血总胆红素比较,无相关性(P＞0.05),GM-CSF在足月儿及早产儿肺炎中无明显差异(P＞0.05).结论:GM-CSF是反应细菌感染的重要指标,对指导抗生素的合理应用具有重要意义.

Changes in Serum Level of GM- CSF in Neonatal Pneumonia

Objective:This study was to investigate the changes of granulocyte-macrophage colony stimulating factor(GM-CSF) in neonatal pneumonia,observe the relationships between GM-CSF and the serum C-reactive protein,granulocyte number,total bilirubin.Methods:We measured the serum levels of GM-CSF in 23 cases neonatal pneumonia by radioimmunoassay(RIA),and measured serum C-reactive protein,granulocyte numaber,total bilirubin.Results: The result of this study were as follows:14 of 23 cases are positive for GM-CSF with a positive rate of 60.89%,9 of 23 cases are positive for CPR with a positive rate of 13.04%,which has statistical significance(P<0.01).GM-CSF levels were positively related to absolute granulocyte number(P<0.01),which has statistical significance.The relationships between GM-CSF levels and total bilirubin,were not observed(P>0.05).There was not a difference between GM-CSF of full-term infants and preterm infants with pneumonia(P>0.05).Conclusions:Serum GM-CSF was an important indicator of bacterial infection and was significant to rational use of antibiotics.