Diagnostic value of tumor markers for differentiating malignant and benign pleural effusions of Iranian patients |
| |
Authors: | Sied Mohammad Ali Ghayumi Samrad Mehrabi Mehrnossh Doroudchi Abbas Ghaderi |
| |
Affiliation: | (1) Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;(2) Departments of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran;(3) Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran |
| |
Abstract: | In order to evaluate the diagnostic yield of tumor markers in differentiating malignant and benign pleural effusions, we carried out a prospective study in a group of Iranian people. Pleural and serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 15-3 (CA15-3), neuron-specific enolase (NSE) and cancer antigen 125 (CA 125) were assayed prospectively in patients with pleural effusion (40 malignant and 37 benign). The highest sensitivity was obtained with a combination of CA 15-3 in serum, and CA 15-3 and CEA in pleural fluid (80%), also with combination of CA 15-3 in serum, and CA 15-3, NSE and CEA in pleural fluid (80%). The highest specificity was obtained with combination of CA 15-3 in serum, and CA 15-3 and NSE in pleural fluid (100%), and also with combination of CA 15-3 in serum, and CA 15-3, NSE and CEA in pleural fluid (100%). |
| |
Keywords: | pleural effusion tumor markers |
本文献已被 PubMed SpringerLink 等数据库收录! |
|