Diagnostic value of tumor markers for differentiating malignant and benign pleural effusions of Iranian patients |
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| Authors: | Sied Mohammad Ali Ghayumi Samrad Mehrabi Mehrnossh Doroudchi Abbas Ghaderi |
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| Institution: | (1) Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;(2) Departments of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran;(3) Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran |
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| Abstract: | In order to evaluate the diagnostic yield of tumor markers in differentiating malignant and benign pleural effusions, we carried
out a prospective study in a group of Iranian people. Pleural and serum levels of carcinoembryonic antigen (CEA), carbohydrate
antigen 15-3 (CA15-3), neuron-specific enolase (NSE) and cancer antigen 125 (CA 125) were assayed prospectively in patients
with pleural effusion (40 malignant and 37 benign). The highest sensitivity was obtained with a combination of CA 15-3 in
serum, and CA 15-3 and CEA in pleural fluid (80%), also with combination of CA 15-3 in serum, and CA 15-3, NSE and CEA in
pleural fluid (80%). The highest specificity was obtained with combination of CA 15-3 in serum, and CA 15-3 and NSE in pleural
fluid (100%), and also with combination of CA 15-3 in serum, and CA 15-3, NSE and CEA in pleural fluid (100%). |
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| Keywords: | pleural effusion tumor markers |
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