| 乙双吗啉和γ射线联合应用对小鼠小肠上皮细胞的影响 |
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| 引用本文： | 冯炎,刘泰福,郑秀英,桑梅仙.乙双吗啉和γ射线联合应用对小鼠小肠上皮细胞的影响[J].复旦学报(医学版),1990(2). |
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| 作者姓名： | 冯炎 刘泰福 郑秀英 桑梅仙 |
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| 作者单位： | 上海医科大学肿瘤医院临床放射生物室
(冯炎，刘泰福，郑秀英)，上海医科大学肿瘤医院临床放射生物室(桑梅仙) |
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| 摘 要： | 本文研究乙双吗啉(AT1727)和γ射线联合应用对动物小肠上皮细胞的作用。腹腔注射AT1727 160mg/kg,在放射前30min给药时,其斜率和单纯放射组相仿,DMF值为1.09;放射后30min给药时,D_o值增加1.3倍,DMF值为1.05。在使用相等分割剂量做分割放射时,显示出他们之间明显的相互作用。结果显示:联合应用增加了辐射生物效应,且和所用药物浓度有关,和二者之间应用次序和相隔时间也有关。
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| 关 键 词： | 乙双吗啉 γ射线 小肠上皮细胞 |
THE COMBINED EFFECT OF BIMOLANE AND IRRADIATION ON MOUSE INTESTINAL CRYPT CELLS |
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| Feng Yan,Liu Ta.ifu,Zheng Xiuying,Sang Meixian.THE COMBINED EFFECT OF BIMOLANE AND IRRADIATION ON MOUSE INTESTINAL CRYPT CELLS[J].Fudan University Journal of Medical Sciences,1990(2). |
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| Authors: | Feng Yan Liu Taifu Zheng Xiuying Sang Meixian |
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| Abstract: | Using the intestinal crypt cell system, the effects of bimolane (AT1727) with mouse irradiation have been studied. AT1727 was administered by i.p.. With combined treatment an increased biological irradiation effect was observed compared to irradiation alone. This effect was drug dose dependent in the range of doses studied. Timing and sequence of the agent have .influence within a period of 3 days. Incomparism with control survival curve 160ng/kg AT1727 given 30min before irradiation produced a parallel shift for lower Lrradiaciou doses.The dose modifying factor (DMF) wag 1.09. But with this drug irradition sequence, the D0 value surprisingly in created by a factor of 1.3 although it displaced the survival curve to left and the DMF of 1.05 was obtained. A primary study of two equally fractionated doses at various intervals with or without AT1727 indicated marked interaction between the two treatment modalities, with possible AT1727 inhibition of irradiation damage repair. |
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| Keywords: | bimolane (AT1727) irradiation intestinal erypt cells |
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