P53、C-erbB-2和VEGF在非小细胞肺癌中的表达及其临床意义

目的探讨P53、C-erbB-2和血管内皮生长因子（VEGF）在非小细胞肺癌中的表达及其临床意义。方法采用免疫组织化学方法对121例非小细胞肺癌组纵进行P53、C-erbB-2和VEGF表达检测。结果P53、C-erbB-2和VEGF的阳性表达率分别为43％、39％和31％。P53蛋白表达与肺癌组织学类犁和P-TNM分期有关（P〈0．05），与肺癌患者年龄、性别、原发肿瘤大小、淋巴结转移和细胞分化程度无关（P〉0．05）。C-erbB-2蛋白表达与肺癌组织学类型和细胞分化程度有关（P〈0．05），与肺癌患者年龄、性别、原发肿瘤大小、淋巴结转移和P-TNM分剐无关（P〉0．05）。VEGF则与肺癌细胞分化程度有关（P〈0．05），与肺癌患者年龄、性别、原发肿瘤大小、淋巴结转移、组织学类型和P-TNM分期无关（P〉0．05）。结论P53、C-erbB-2和VEGF可能在非小细胞肺癌发牛发展的过程中起重要调控作用。

The Expressions and Clinical Significances of P53, C-erbB-2 and VEGF in Non-Small Cell Lung Cancer

Objective To investigate the expressions and clinical significance of P53,C-erbB-2 and VEGF in non-small cell lung cancer(NSCLC).Methods 121 specimens of NSCLC were examined for P53,C-erbB-2 and VEGF by immunohistochemical staining.Results The positive rates of P53,C-erbB-2 and VEGF in the carcinomatic tissues were 43%,39% and 31% respectively.P53 protein expressions in lung cancer were significantly related to histological type and P-TNM stage of lung cancer patients(P <0.05),and were not associated with the sex,age,the size of primary cancer,lymph node metastasis and cell differentiation(P >0.05).C-erbB-2 gene protein expressions in lung cancer were closely related to histological type and cell differentiation(P <0.05),and were not associated with the sex,age,the size of primary cancer,lymph node metastasis and P-TNM stage of lung cancer patients(P >0.05).VEGF in lung cancer was only closely related to cell differentiation(P <0.05),and was not associated with the sex,age,the size of primary cancer,lymph node metastasis,histological type and P-TNM stage of lung cancer patients((P >0.05)).Conclusions It is possible for P53,C-erbB-2 and VEGF to play an important role in the tumor generation and development of nonsmall cell lung cancer.