| 子宫平滑肌肿瘤组织bcl-2蛋白表达的研究 |
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| 引用本文： | 孙立奇,石一复. 子宫平滑肌肿瘤组织bcl-2蛋白表达的研究[J]. 中华肿瘤防治杂志, 2004, 11(2): 137-139 |
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| 作者姓名： | 孙立奇 石一复 |
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| 作者单位： | 浙江大学医学院附属妇产科医院,浙江,杭州,310006 |
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| 摘 要： | 目的 :了解bcl 2蛋白在子宫平滑肌肿瘤 (USMTs)的表达和意义。方法 :在 2 0例良性子宫平滑肌瘤 (UL)、18例子宫平滑肌肉瘤 (LMS)及 70例交界性子宫平滑肌瘤(BLM )中 ,应用免疫组织化学法检测bcl 2蛋白的表达。结果 :UL组bcl 2蛋白表达阳性率明显高于LMS组 ,P <0 0 5 (18例 /10例 ) ;BLM组bcl 2蛋白表达阳性率显著高于LMS组 ,P <0 0 1(62例 /10例 )。结论 :bcl 2蛋白过度表达对细胞凋亡旁路的抑制可能在USMT的发生、发展起到重要的作用
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| 关 键 词： | 子宫肿瘤/病理学 平滑肌瘤/病理学 bcl-2蛋白 免疫组织化学 |
| 文章编号： | 1009-4571(2004)02-0137-03 |
| 修稿时间： | 2003-07-08 |
Expression and significance of bcl-2 protein in human uterine smooth muscle tumors |
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| SUN Li qi,SHI Yi fu Women's Hospital,Zhejiang University School of Medicine,Hangzhou ,P.R.China. Expression and significance of bcl-2 protein in human uterine smooth muscle tumors[J]. Chinese Journal of Cancer Prevention and Treatment, 2004, 11(2): 137-139 |
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| Authors: | SUN Li qi SHI Yi fu Women's Hospital Zhejiang University School of Medicine Hangzhou P.R.China |
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| Affiliation: | SUN Li qi,SHI Yi fu Women's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,P.R.China |
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| Abstract: | OBJECTIVE:To investigate the expression and significance of bcl 2 protein in human uterine smooth muscle tumors (USMTs).METHODS:The immunohistochemical technique was used to detect the bcl 2 protein expressions in 20 usual leiomyoma (UL),70 borderline leiomyoma (BLM) and 18 leiomyosarcoma (LMS).RESULTS:The positive bcl 2 protein expression rate of UL was significantly higher than that of LMS , P <0 05;the positive bcl 2 protein expression rate of BLM was significantly higher than that of LMS, P <0 01.CONCLUSIONS:The inhibition of the induction of apoptosis by bcl 2 protein overexpression might play an important role in human uterine smooth muscle tumors. |
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| Keywords: | uterine neoplasm/pathology smooth muscle tumor/pathology bcl 2 protein immunohistochemistry |
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