奎硫平和利培酮治疗首发精神分裂症对照研究

目的对比奎硫平与利培酮治疗首发精神分裂症的疗效和安全性。方法分别以奎硫平与利培酮治疗首发精神分裂症60例，采用阳性与阴性症状量表（PANSS）、副反应量表（TESS），在治疗前及治疗后第1、2、4、8周末分别评定疗效及不良反应。结果奎硫平有效率86．7％，显效率76．7％，利培酮有效率80．0％，显效率66．7％。两组治疗后与治疗前的PANSS评分比较差异有显著性（P〈0．01）。奎硫平不良反应少于利培酮。结论奎硫平治疗精神分裂症疗效好。不良反应较利培酮轻微，病人服药依从性好。

A Comparative Study of Quetiapine and Risperdal in the Treament of First-onset Schizophrenia

Objective To compare the efficacy and safety between quet ia pine and risperdal in the treatment of first-onset schizophrenia.Methods 60 schizophrenic patients were treated with quetiapine and ano ther sixty patients treated with risperdal. The efficacy was measured with the p ositive and negative symptoms scale(PANSS), while the side effects were determin ed by the treatment emergent sympyom scale(TESS). Results The e fficacy rate of quetiapine was 86.7%, in which 76.7% were improved markedly. The efficacy rate o f risperdal was 80.0%, in which 66.7% were improved markedly. The PANSS scores i n both groups decreased significantly after treatment. Quetiapine has less side effects than risperdal. Conclusion Quetiapine is a drags of eff icacy, high safe ty and less side effects in treating schizophienia, and patients had better comp liance.