| 肾癌KAI—1基因表达与浸润转移的关系 |
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| 引用本文： | 孙宪国 张元芳. 肾癌KAI—1基因表达与浸润转移的关系[J]. 中国癌症杂志, 1999, 9(3): 229-230,240 |
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| 作者姓名： | 孙宪国 张元芳 |
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| 作者单位： | 上海医科大学华山医院泌尿外科!上海200040 |
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| 摘 要： | 目的 研究ＫＡＩ １ 基因在肾细胞癌的表达状况。 方法 采用逆转录 多聚酶链反应（ＲＴ ＰＣＲ） 技术检测２２ 例肾癌及２２ 例非癌肾组织ＫＡＩ １ ｍ ＲＮＡ 的表达。 结果 １６ 例肾癌及２２ 例非癌肾组织表达ＫＡＩ １ ｍＲ ＮＡ,癌组织的表达阳性率显著低于非癌组织（ Ｐ＜ ００５） ;有肾外浸润或淋巴结转移移的肾癌组织阳性率显著低于无浸润转移者（ Ｐ＜ ００１）。 结论 ＫＡＩ １ 基因的低表达可促进肾癌细胞转移。
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| 关 键 词： | 肾肿瘤 KAI－1基因 肿瘤浸润 肿瘤转移 |
EXPRESSION OF KAI 1 IN RENAL CELL CARCINOMAS AND CORRELATION WITH EXTRA RENAL INVASION AND METASTASIS |
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| Kong Xianguo,Zhang Yuanfang,Ding Qiang,et al.. EXPRESSION OF KAI 1 IN RENAL CELL CARCINOMAS AND CORRELATION WITH EXTRA RENAL INVASION AND METASTASIS[J]. China Oncology, 1999, 9(3): 229-230,240 |
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| Authors: | Kong Xianguo Zhang Yuanfang Ding Qiang et al. |
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| Abstract: | To study the expression of KAI 1 gene in renal cell carinomas.METHODS The reverse transcription polymerase chain reaction (RT PCR) was used to detect expression of KAI 1 mRNA in specimens from 22 primary renal cell carcinomas and 22 non tumor kidney tissues.RESULTS KAI 1 mRNA expression was positive in 16 of 22 renal cell carcinomas and 22 of 22 non tumor tissues.The positive rate of KAI 1 in renal cell carcinomas was significantly lower ( P <0 05) than that in non tumor tissues,and it was significantly lower ( P <0 01) in advanced tumor stages in which extra renal invasion or lymph node mtastases were persent,compared with early tumor stages.CONCLUSION The reduction of KAI 1 expression might enable renal cancer cells to spread. |
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| Keywords: | Kidney neoplasm Carcinoma Metastasis suppressor gene KAI 1 |
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