脑膜瘤Ki—67MIB—1的表达及其诊断价值

目的　研究肿瘤细胞增殖活性及其在诊断脑膜瘤中的价值。　方法　应用Ｋｉ６７ ＭＩＢ１ 免疫组织化学方法，检测其在脑膜瘤中的表达。　结果　良性脑膜瘤的Ｋｉ６７ ＭＩＢ１ 平均指数为２４５％ ，非典型脑膜瘤为５５ ％ ，恶性脑膜瘤为１１２ ％ 。良性脑膜瘤与非典型脑膜瘤比较差异有显著性（ Ｐ＜ ０００１），非典型脑膜瘤与恶性脑瘤比较差异有显著性（ Ｐ＜ ０００１） 。核分裂与Ｋｉ６７ ＭＩＢ１ 表达呈相关性（ｒ＝ ０７７９ ，Ｐ＜０００１）。　结论　Ｋｉ６７ＭＩＢ１ 染色有助于脑膜瘤的正确诊断。

Ki 67 MIB 1 EXPRESSION AND ITS DIAGNOSTIC VALUE FOR MENINGIOMAS OF CENTRAL NERVOUS SYSTEM

To investigate tumor cell proliferating activity and its diagnostic value for meningiomas of central nervous system.METHODS Assay of Ki 67 MIB 1 was done by a monoclonal antibody immunohistochemical method. RESULTS The mean Ki 67 MIB 1 index values of benign,atypical and malignant ones were 2.45%, 5.5% and 11.2%,respectively.Significant deference was found in mean Ki 67 MIB 1 indices of benign tumors and atypical tumors( P <0 001),also in mean Ki 67 MIB 1 indices of atypical tumors and malignant meningiomas( P <0 001). There was a good correlation between mitotic figure count and Ki 67 MIB 1 expression (r=0 779, P <0 001). CONCLUSIONS It is suggested that Ki 67 MIB 1 staining is helpful in making correct diagnosis for meningiomas of central nervous system.