| 阿立哌唑与利培酮治疗精神分裂症随机双盲对照研究 |
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| 引用本文： | 徐筠,李朝,王慧芳,李华芳.阿立哌唑与利培酮治疗精神分裂症随机双盲对照研究[J].临床精神医学杂志,2010,20(1):35-37. |
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| 作者姓名： | 徐筠 李朝 王慧芳 李华芳 |
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| 作者单位： | 上海市精神卫生中心,200030 |
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| 摘 要： | 目的：评价阿立哌唑治疗精神分裂症的有效性和安全性。方法：将52例精神分裂症患者，随机分配到阿立哌唑组26例和利培酮组26例，进行为期6周的随机双盲对照研究。采用阳性和阴性症状量表（PANSS）、临床疗效总评量表（CGI）、治疗中出现的症状量表（TESS）及有关实验室检查评定疗效和安全性。结果：治疗6周两组PANSS评分较治疗前均显著降低（P均〈0．05），各时点PANSS评分两组间减分差异无统计学意义。治疗6周末，阿立哌唑组有效率58．3％，利培酮有效率75％，两组比较差异无统计学意义（χ^2=1．50，P=0．221）。两组均未发生严重相关不良事件。阿立哌唑组对血清催乳素的影响较利培酮组小。结论：阿立哌唑治疗精神分裂症的疗效与利培酮相当，对催乳素无影响，是一种安全而有效的抗精神病药物。
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| 关 键 词： | 阿立哌唑 利培酮 精神分裂症 |
Randomized double blind control study of aripiprazole and risperidone on the treatment of schizophrenia |
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| XU Yun,LI Chao,WANG Hui-fang,Li Hua-fang.Randomized double blind control study of aripiprazole and risperidone on the treatment of schizophrenia[J].Journal of Clinical Psychological Medicine,2010,20(1):35-37. |
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| Authors: | XU Yun LI Chao WANG Hui-fang Li Hua-fang |
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| Institution: | XU Yun,LI Chao,WANG Hui-fang,Li Hua-fang.Shanghai Mental Health Center,Shanghai 200030,China |
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| Abstract: | Objective: To assess the efficacy and safety of aripiprazole on the treatment of schizophrenia. Method:A randomized,double-blind,double-dummy,comparative study was performed with a course of 6 weeks.Fifty-two Patients with schizophrenia were randomized into aripiprazole group(n=26) and risperidone group(n=26).The positive and negative syndrome scale(PANSS),clinical global impression(CGI),treatment emergent symptom scale(TESS) were used to asess the effectiveness and the safety of the treatment. Results:By t... |
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| Keywords: | aripiprazole risperidone schizophrenia |
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