2008年Mohnarin脑脊液分离菌耐药性分析

目的了解我国中枢神经系统感染细菌的分布及耐药状况。方法采用纸片法、MIC法或E-test法测定细菌药物敏感性,使用WHONET5.4软件进行分析,对卫生部全国细菌耐药性监测网(Mohnarin)所属三级甲等医院2008年1月1日-12月31日分离的脑脊液标本菌株进行分析。结果共有48所医院从脑脊液标本分离出细菌1181株,其中革兰阳性菌679株,占57.5%,革兰阴性菌502株,占42.5%;最常见的革兰阳性菌依次为凝固酶阴性葡萄球菌372株、金黄色葡萄球菌143株、肠球菌属91株和链球菌属51株,最常见的革兰阴性菌依次为大肠埃希菌113株、不动杆菌属111株,克雷伯菌属85株和铜绿假单胞菌43株;耐甲氧西林金黄色葡萄球菌和凝固酶阴性葡萄球菌的检出率分别为70.5%和74.3%,未发现耐万古霉素金黄色葡萄球菌和凝固酶阴性葡萄球菌;发现耐糖肽类药物屎肠球菌,大肠埃希菌和肺炎克雷伯菌中产ESBLs的比率分别为59.3%和46.1%。结论我国中枢神经系统感染最常见的细菌为凝固酶阴性葡萄球菌,外科组不动杆菌属所占比例较内科组高,儿童组革兰阳性菌所占比例较成人组更高;脑脊液来源的MRSA发生率、大肠埃希菌和肺炎克雷伯菌中产ESBLs的比率高于同期整体水平。

Mohnarin Report of 2008: Drug Resistance of Bacteria Isolated from CSF

OBJECTIVE To explore the distribution and resistance of bacteria isolated from central nervous system.METHODS The Disc diffusion test,MIC test and E-test were used to detect the antimicrobial sensitivity of bacterial isolates.WHONET 5.4 was applied for analyzing the bacterial sensitive data from Mohnarin member hospitals in China from Jan1 to Dec 31,2008.RESULTS A total of 1181 strains of bacteria were isolated from cerebral spinalfluid(CSF) in 48 hospitals,including 679 (57.5%) Gram positive strains and 50...