补肾活血方对BPH大鼠前列腺组织中VEGF、bFGF表达的影响

目的：评价补肾活血方对BPH大鼠的疗效，并探讨其作用机理。方法：实验研究采用SD大鼠去势后皮下注射丙酸睾丸酮法复制BPH模型，用形态计量学方法研究各组前列腺组织的形态改变；用免疫组化法研究实验各组前列腺组织的血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）的表达。结果：补肾活血方可以缩小增生前列腺腺体的体积，并抑制VEGF、bFGF的表达。结论：补肾活血方用于治疗BPH，能缩小前列腺体积，作用机理是可能是通过抑制VEGF、bFGF的表达，进而抑制前列腺增生。

Effect of Bushenhuoxue Decoction on the Expression of VEGF and bFGF in the Tissue of Model Rats with Benign Prostatic Hyperplasia

Objective： To evaluate the effect of Bushenhuoxue decoction （BSHX） on the model rats with benign prostatic hyperplasia （BPH）, and to explore the function mechanism. Methods： The BPH model was established by subcutaneously injecting methylacetic acid testosterone to emasculated rats. The morpliological changes in prostate tissue of every group were studied with morphometry. The immunohistechemistry method was adopted to study the expression of vascular endothelial growth factor （VFAGF） and basic fibroblast growth factor （bFGF） in prostate tissue. Results： BSHX diminished the gland vohane of prostate and inhibited the expression of VEGF and bFGF in prostate tissue. Conclusion： In the treatment of BPH, BSHX can diminish the prostate gland volume, possibly by inhibiting the expression of VEGF and bFGF in prostate gland tissue to inhibit the hyperplasia of prostatic gland cells.