血清缺血修饰白蛋白、心肌肌钙蛋白和高敏C反应蛋白检测对急性心肌梗死的早期诊断价值

目的 探讨急性心肌梗死(AMI)患者血清缺血修饰白蛋白(IMA)、心肌肌钙蛋白Ⅰ(cTnI)以及高敏C反应蛋白(hs-CRP)的浓度变化,为AMI早期诊断提供较合理的临床依据和检测指标.方法 选择AMI患者66例,以开始发作胸痛到就诊时间为分组依据,将胸痛0～4h作为E组(39例),胸痛4～8h作为F组(27例).另选择同期健康体检者59例作为对照组.即时采集血清样本.进行IMA、cTnI以及hs-CRP的浓度水平检测.结果 E组血清IMA、cTnI以及hs-CRP水平显著高于对照组(P＜0.05或P＜0.001),但除IMA浓度高于正常参考值外,cTnI和hs-CRP的浓度均在正常参考值范围内.F组血清IMA、cTnI以及hs-CRP水平显著高于对照组(均P＜0.05),且均高于正常参考值.结论 IMA、cTnI以及hs-CRP可作为AMI早期诊断的有效指标,联合检测有助于AMI早期确诊,为病情治疗和发展提供可靠依据.

The diagnostic value of serum IMA, cTnI and hs-CRP in early diagnosis for acute myocardial infarction

Objective To provide a reasonable clinical evidence and testing index for acute myocardial infarction （AMI） early diagnosis by investigating the levels of serum ischemla-modified album（IMA） , cardiac troponin I（eTnI） and high-sensitivity C-reactive protein （hs-CRP） in patients with AMI. Methods 66 cases with AMI were divided into two groups by the time of starting attack chest pain to clinic, the time of 0-4h as E group （39 cases） ,4- 8h as F group （27 cases） , another 59 healthy persons in the control group were deteaed. Then collected serum sam- ples from each case to detect the concentration of the IMA, cTnI and hs-CRP. Results The levels of serum IMA, cTnI and hs-CRP in E group were significantly higher than those in the control group （P 〈 0.05 or P 〈 0.001 ）, in addition to the IMA level was higher than normal, cTnI and hs-CRP levels were in the normal range. The levels of serum IMA, cTnI and hs-CRP in F group were significantly higher than the levels of control group（ P 〈0.05 ） and also above the normal. Conclusion IMA,cTnl and hs-CRP not only can be used as the effective index for AMI early diagnosis,but also help for early diagnosis. The results provide a reliable basis for disease treatment and condition development.