Primary B-cell lymphoma of the cauda equina, successfully treated with high-dose methotrexate plus high-dose cytarabine: a case report with MRI findings |
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Authors: | Hiroko Nishida Masao Hori Katsuyuki Obara |
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Institution: | (1) Department of Internal Medicine, Mito Red Cross Hospital, 3-12-48 Sannoaru, Mito Ibaragi, 310-0011, Japan;(2) Department of Pathology, Mito Red Cross Hospital, Mito, Ibaragi, Japan;(3) Department of Internal Medicine and Neurology, Mito Red Cross Hospital, Mito, Ibaragi, Japan;(4) Departnent of Internal Medicine and Pathology, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan |
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Abstract: | Primary malignant lymphoma of the cauda equina is an extremely rare disease. Previously, there have been only 12 reported
cases of malignant lymphoma of the cauda equina, and most cases relapsed early in the clinical course. So, the optimal treatment
strategy for this condition has not been established yet and the prognosis is thought to be poor. We experienced a case of
B-cell malignant lymphoma of the cauda equina, with rapid progression of the muscle weakness of the bilateral lower extremities,
successfully treated with high-dose methotrexate plus high-dose cytarabine (Ara-C) chemotherapy, followed by radiotherapy
and in complete remission without any recurrence signs, 1.5 years after the initial diagnosis. Intrathecal chemotherapy with
MTX, Ara-C, and predonisolone was simultaneously performed. We should carefully continue to monitor the clinical course of
our case, with the examinations of magnetic resonance imaging and cerebrospinal fluid in order not to overlook any subtle
neurological changes or other clinical symptoms. |
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Keywords: | |
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