Expression of both hepatocellular carcinoma and cholangiocarcinoma phenotypes in hepatocellular carcinoma and cholangiocarcinoma components in combined hepatocellular and cholangiocarcinoma |
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Authors: | Mitsumaro Itoyama Masaki Hata Koji Yamanegi Naoko Yamada Hideki Ohyama Hiroshi Hirano Nobuyuki Terada Keiji Nakasho |
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Institution: | Department of Pathology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan. |
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Abstract: | Expression of phenotype markers of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) in HCC and CC components of
20 combined hepatocellular and cholangiocarcinomas (CHCs) of the liver was investigated immunohistochemically. Both HCC and
CC components of all CHCs expressed at least one of the CC phenotype markers cytokeratin (CK)-7, CK-19, and carbohydrate
(CA) 19-9]. HCC components in 90% of CHCs and CC components in 95% of CHCs expressed at least one of these CC phenotype markers
in more than 40% of cancer cells. HCC components in all CHCs expressed at least one of the HCC phenotype markers hepatocyte
antigen (HA), α-fetoprotein (AFP), and canalicular carcinoembryonic antigen]. HCC components in 90% of CHCs and CC components
in 75% of CHCs expressed HA, AFP, or both. HCC components in 75% of CHCs and CC components in 60% of CHCs expressed HA, AFP,
or both in more than 10% of cancer cells. The present results show that both HCC and CC components of most of the CHCs expressed
both HCC and CC phenotypes, supporting the hypothesis that CHC originates from a hepatic progenitor cell capable of differentiating
into hepatocytes and cholangiocytes. |
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Keywords: | |
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