百部复方消痤膏治疗寻常性痤疮

目的:观察百部复方消痤膏治疗寻常性痤疮的临床疗效及探讨其作用机制.方法:将130例寻常痤疮(Ⅰ级～Ⅱ级)患者随机分为治疗组、对照组.治疗组用百部复方消痤膏,每天早、晚各用温水洗脸后涂于皮损处；对照组用过氧化苯甲酰凝胶,每天早、晚各用温水洗脸后涂于皮损处.两组均治疗8周,比较两组患者临床疗效,观察两组患者治疗前及治疗后2,4,6,8周时粉刺、脓疱、总皮损减少率及不良反应,并观察体外抑菌杀螨效果.结果:治疗组有效率92.30％,对照组有效率67.26％,治疗组明显优于对照组(P＜0.01).两组中的粉刺、脓疱、总皮损治疗后减少率均具有统计学意义(P＜0.05).其中,第4,6,8周粉刺减少率治疗组优于对照组(P＜0.01)；第2,4,6,8周脓疱减少率治疗组优于对照组(P＜0.01).百部复方消痤膏外用无不良反应.体外抑菌杀螨实验表明,百部复方消痤膏对痤疮致病菌群的抑制作用优于对照组,同时对蠕形螨虫也有较好的杀灭作用.结论:百部复方消痤膏治疗寻常痤疮疗效好,作用快速,无不良反应,其机制与抗炎、抑菌、杀螨有关.

Stemona Compound Eliminate Acne Ointment External Treatment of Acne Vulgaris Clinical and Experiment Research

Objective: To observe clinical curative effect and explore the mechanism of stemona compound eliminate acne ointment in the treatment of acne vulgaris. Method: One hundred and thirty Acne Vulgaris patients were randomly divided into a treatment group and control group. In treatment group the patients washed their face with warm water and applied the stemona compound superfine grinding to the skin lesions in every morning and evening. In the control group the patients would do the same but use benzoyl peroxide gel applied to the skin lesions. Both two groups were treated for 8 weeks. Before treatment and 2, 4, 6 and 8 weeks after the treatment, the two groups were assessed by acne, pustules, the total lesions reduce rate and adverse reactions, and clinical efficacy was compared in two groups. Result: The effective rate of treatment group 92.30%,control group was 67.26%, significantly better than the control group (P<0.01). The depletion rate of acne, pustules, skin lesions after treatment in the two groups was statistically significant (P<0.05). Among them, the acne treatment depletion rate of the fourth week,sixth week, eighth week was better than control group (P<0.01); the pustules depletion rate of the second week, forth weeks, sixth weeks, eighth week also was better than in control group (P<0.01). Stemona compound eliminate acne ointment has no adverse reaction ointment. Vitro antibacterial acaricidal experiments show that stemona compound eliminate acne ointment on inhibition of pathogenic bacteria of acne is better than that of control group, but also has good killing effect on Demodex mites. Conclusion: Stemona compound eliminate acne ointment in the treatment of acne vulgaris is good, fast, no adverse reaction,and it also have the effect on anti-inflammatory, antibacterial, acaricidal.