Micromechanical Characterization of Intra-luminal Thrombus Tissue from Abdominal Aortic Aneurysms |
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Authors: | T Christian Gasser Giampaolo Martufi Martin Auer Maggie Folkesson Jesper Swedenborg |
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Institution: | 1.Department of Solid Mechanics,Royal Institute of Technology (KTH),Stockholm,Sweden;2.VASCOPS GmbH, SciencePark Graz,Graz,Austria;3.Department of Vascular Surgery,Karolinska University Hospital and Institute,Stockholm,Sweden |
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Abstract: | The reliable assessment of Abdominal Aortic Aneurysm rupture risk is critically important in reducing related mortality without
unnecessarily increasing the rate of elective repair. Intra-luminal thrombus (ILT) has multiple biomechanical and biochemical
impacts on the underlying aneurysm wall and thrombus failure might be linked to aneurysm rupture. Histological slices from
7 ILTs were analyzed using a sequence of automatic image processing and feature analyzing steps. Derived microstructural data
was used to define Representative Volume Elements (RVE), which in turn allowed the estimation of microscopic material properties
using the non-linear Finite Element Method. ILT tissue exhibited complex microstructural arrangement with larger pores in
the abluminal layer than in the luminal layer. The microstructure was isotropic in the abluminal layer, whereas pores started
to orient along the circumferential direction towards the luminal site. ILT’s macroscopic (reversible) deformability was supported
by large pores in the microstructure and the inhomogeneous structure explains in part the radially changing macroscopic constitutive
properties of ILT. Its microscopic properties decreased just slightly from the luminal to the abluminal layer. The present
study provided novel microstructural and micromechanical data of ILT tissue, which is critically important to further explore
the role of the ILT in aneurysm rupture. Data provided in this study allow an integration of structural information from medical
imaging for example, to estimate ILT’s macroscopic mechanical properties. |
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